Treatment Options for Testosterone Replacement Therapy
What treatments are available?
The transdermal gel/solution contains native testosterone in a clear and colorless formulation which is absorbed by the skin within a few minutes after the morning application to the upper arms, shoulders and abdomen, without leaving any residue. The serum testosterone concentration remains very reliably within the normal range for 24 hours after application.2,4,6 A new testosterone formulations is an underarm transdermal solution (Axiron®).
In summary, testosterone patches are transdermal formulations of native testosterone applied to the skin of the abdomen, back, shoulders, upper arms or thighs (or scrotum, in the case of scrotal patches). Although a steady absorption of testosterone is provided over a 24-hour period, some men may require two patches daily to achieve serum testosterone levels in the middle of the normal physiological range recommended as a goal for testosterone replacement therapy.1
Oral testosterone undecanoate has the convenience of oral administration without the same potential for liver toxicity as another oral testosterone formulation, 17-α-testosterone.1-4 However, a short duration of action requires 2-3 times daily dosing, and clinical responses are less consistent than with the long-acting injectable formulation of testosterone undecanoate or the testosterone gel.1,2