1. Testosterone levels:
Pharmacokinetic studies have shown that Nebido®
maintains testosterone levels within the physiologic range. The recommended administration regime consists of one loading dose 6 weeks after the initial injection followed by intervals of 10 to 14 weeks (usually 3 months The initial short interval (loading dose) is advisable to quickly achieve steady state conditions. In order to adjust the treatment regimen to individual needs, a blood sample prior to the 4th
injection, i.e. at trough level, is suggested. If testosterone levels are below the normal range, a shortening of the interval to 10 weeks may be considered. If testosterone levels are in the lower third of the normal range the 3-monthly interval should be maintained. If testosterone levels are above the lower third of the normal range, an extension of injection intervals can be considered. In any case, the clinical symptomatology of the patient must be taken into consideration.
2. Clinical symptoms:
As a consequence of the restoration of testosterone levels, significant improvements of certain clinical signs associated with the androgen deficit can be shown:
- Nebido® has a favorable effect on body composition by increasing muscle mass and decreasing fat mass.
- Muscle strength improves under therapy with Nebido®.
- Sexual function parameters are improved with Nebido®.
- Nebido® exerts a positive effect on mood, thus improving self-confidence and activity, and reduces fatigue and the feeling of exhaustion.