Latest research on testosterone deficiency and its treatment.

Male hypogonadism is a clinical syndrome resulting from a failure of the testes to produce physiological levels of testosterone (androgen deficiency), sperm, or both, because of disruption of one or more levels of the hypothalamic-pituitary-gonadal axis.

The symptoms of hypogonadism may vary from individual to individual. In late-onset hypogonadism many symptoms resemble those of aging and as a consequence this condition is often un-diagnosed. Various diagnostic procedures are available to confirm hypogonadism in a patient who presents with symptoms or signs of testosterone deficiency.

Testosterone replacement therapy is characterized by a wide margin of safety and good tolerability. Treatment can be initiated when a diagnosis of hypogonadism has been confirmed and contraindications ruled out. Close monitoring of the treatment is essential.

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