Categories

You can filter the research news archive by selecting one or multiple categories from the following list.






















  Show all news

 

15 August 2017

Effective testosterone treatment reduces incidence of atrial fibrillation

Effective testosterone treatment reduces incidence of atrial fibrillation

Sharma, R., et al., Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation. J Am Heart Assoc, 2017. 6(5)

While the effect of testosterone treatment on heart disease is a topic of ongoing debate, a growing body of evidence is refuting the widespread belief that testosterone treatment supposedly is harmful in terms of heart disease risk.

Here we report the results of a study, published in the Journal of the American Heart Association, which investigated the effect of testosterone treatment on the incidence of atrial fibrillation - an irregular and often rapid heart rate that can increase risk of stroke, heart failure and other heart-related complications - in testosterone deficient men with documented low testosterone levels.

Key Points

  • Atrial fibrillation is the most common form of abnormal heart rhythm, causing significant morbidity, mortality, and financial burden, especially in older men.
  • Effective testosterone treatment that achieves large enough elevations in testosterone levels reduces the incidence of atrial fibrillation by up to 21%.
  • Ineffective testosterone treatment, which does not achieve large enough elevations in testosterone levels, does not confer benefits.

28 July 2015

Long-term testosterone treatment with different testosterone preparations

Long-term testosterone treatment with different testosterone preparations

- provocative results on diagnosis and adherence

Due to lack of consistent clear-cut guidelines for diagnosis and treatment of testosterone deficiency, there is a lot of confusion among both health professionals and suffering men. The multiple different testosterone preparations available further add to the complexity of testosterone treatment.

This editorial presents the intriguing results from a notable study that analyzed effects of testosterone therapy with seven different testosterone preparations, in symptomatic men who had previously been denied treatment because of "normal" baseline testosterone levels. The results are quite provocative and highlight several important practical issues relating to diagnosis and treatment of hypogonadism…

1 February 2015

Adherence to testosterone therapy

Adherence to testosterone therapy

Long-term treatment patterns of testosterone replacement medications.
Donatucci C, Cui Z, Fang Y, Muram D. The journal of sexual medicine. Aug 2014;11(8):2092-2099.

Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis.
Schoenfeld MJ, Shortridge E, Cui Z, Muram D. The journal of sexual medicine. May 2013;10(5):1401-1409.

Testosterone therapy confers a wide range of health benefits for hypogonadal men, including improvements in body composition (reduction in body fat, increase in muscle mass, weight loss), lipid profile, cardiovascular function, insulin sensitivity/glucose metabolism, bone mineral density, inflammatory parameters, quality of life and potentially longevity.

Despite this, there is a high discontinuation rate with testosterone therapy. This editorial presents findings from two studies which have investigated adherence to testosterone therapy and treatment patterns.


Last updated: 2019
G.MKT.GM.MH.02.2018.0506