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15 December 2018

Muscle and strength gains during testosterone therapy are greater with testosterone injections than gels

Muscle and strength gains during testosterone therapy are greater with testosterone injections than gels
Does it matter which testosterone preparation is prescribed for testosterone therapy? This is a common question among HCPs as well as patients. A new meta-analysis shows that testosterone therapy with injectable testosterone preparations results in larger muscle and strength gains compared to transdermal testosterone preparations. This has important implications for the growing population of men with hypogonadism, who are at high risk of lean (muscle) mass loss, obesity, diabetes and sarcopenia.

15 August 2018

Hypogonadism, Muscle Weakness, and Multi-morbidity in Men

Hypogonadism, Muscle Weakness, and Multi-morbidity in Men

Hypogonadism (testosterone deficiency) is more common than previously thought, even in younger men. Men with hypogonadism – regardless of age – have a higher prevalence of muscle weakness and simultaneous occurrence of several risk factors and chronic diseases.

Considering the strong association between low testosterone and multimorbidity even in young men, it is possible that low testosterone may play a causal role in chronic disease development, such as obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes, the prevalence of which has reached epidemic proportions over the last decade. Early detection and treatment of low testosterone, particularly in younger men, could possibly slow progression, or potentially stop disease development entirely.

15 May 2017

Effects of Testosterone Therapy for 3 Years on Muscle Performance and Physical Function in Older Men

Effects of Testosterone Therapy for 3 Years on Muscle Performance and Physical Function in Older Men

Declining testosterone levels – which is commonly seen in men as they get older - are associated with reduced lean body mass, muscle strength, physical function and performance. Evidence for a causal-effect relationship between testosterone levels and lean body (muscle) mass comes from several studies which have shown that testosterone treatment consistently increases lean body mass (which is a proxy measure for muscle mass).

Here we summarize the results of the long-term TEAAM (Testosterone’s Effects on Atherosclerosis Progression in Aging Men) study, which also investigated effects of testosterone treatment on muscle performance, physical function, and lean body mass.

Key Points

  • The TEAAM study enrolled men aged 60 years or older with low-normal testosterone levels, 3.5 - 13.9 nmol/L (100 and 400 g/dL) or free testosterone level less than 174 pmol/L (50 pg/mL).
  • Testosterone treatment for 3 years increased lean body mass, muscle strength and power, despite absence of exercise.
  • Men in the placebo group showed a decline in lean body mass, muscle strength and power, suggesting that long-term testosterone treatment not only prevents the age-related loss in muscle function, but actually improves muscle function.
  • Treatment effects tended to wane over time in parallel with the dropping testosterone levels. This underscores the importance of long-term adherence to testosterone treatment in order to realize benefits.

Last updated: 2019
G.MKT.GM.MH.02.2018.0506