Data strongly suggests a relationship between testosterone deficiency and frailty in elderly men
- However, it should be noted that frailty is a composite syndrome and not all aspects of frailty will be ameliorated by testosterone therapy
What is known
What this study adds
This review demonstrated that, although frailty is a complex condition, the evidence suggests that testosterone therapy in frail elderly men with low testosterone level improves body composition and axial bone mineral density and physical function while ameliorating a number of risk factors for CVD. Although frailty is a composite syndrome and not all aspects of frailty will be ameliorated by testosterone therapy, available data strongly suggest a relationship between testosterone deficiency and frailty and warrant further investigation to determine those frail elderly men most likely to benefit from testosterone therapy and to define the role of testosterone therapy in the management of elderly men with frailty.
- Saad F. The relationship between testosterone deficiency and frailty in elderly men. Horm Mol Biol Clin Invest 2010;4(1):529-538. Return to content
- Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146-156. Return to content
- Pel-Littel RE, Schuurmans MJ, Emmelot-Vonk MH, et al. Frailty: defining and measuring of a concept. J Nutr Health Aging 2009;13(4):390-394. Return to content