Regimen: Injections every 3rd month = 4 times per year
Description: The long-acting injectable formulation of testosterone undecanoate was developed to overcome the shortcomings of conventional testosterone injections, usually requiring only four injections per year to maintain testosterone levels constantly in the eugonadal range, without the non-physiological peaks and troughs associated with conventional short-acting testosterone injections.12
Preparations like testosterone undecanoate are easier to administer (compared to older preparations such as testosterone Enathate) and provide more stable physiological levels of testosterone, avoiding the roller-coaster spikes and drops in testosterone levels and risk of ensuing mood swings and excessive hematocrit elevations.
Patients value the consistent, reliable efficacy and the long duration of effect, which means they are not dependent on taking frequent medication.13,14
Consequently, testosterone undecanoate is likely to become the standard preparation for long-term testosterone therapy. One of such preparations is injectable longacting testosterone undecanoate (Nebido®).