Precautions

Although there is no evidence that long term use of testosterone therapy can cause prostate cancer, testosterone may accelerate pre-existing prostate cancer. Testosterone therapy should not be used by men with active prostate cancer or a history of prostate cancer, or by men with the very rare male breast cancer, because testosterone can stimulate these cancers to grow.

Cases of benign and malignant liver tumours have been reported in users of hormonal substances such as androgen compounds. If severe upper abdominal complaints, liver enlargement or signs of intra-abdominal haemorrhage occur in men using Nebido, a liver tumour should be included in the differential-diagnostic considerations. In patients suffering from severe cardiac, hepatic or renal insufficiency or ischemic heart disease, treatment with testosterone may cause severe complications characterized by oedema with or without congestive cardiac failure.

How to diagnose hypogonadism in men?

Cases of benign and malignant liver tumours have been reported in users of hormonal substances such as androgen compounds. If severe upper abdominal complaints, liver enlargement or signs of intra-abdominal haemorrhage occur in men using Nebido, a liver tumour should be included in the differential-diagnostic considerations. In patients suffering from severe cardiac, hepatic or renal insufficiency or ischemic heart disease, treatment with testosterone may cause severe complications characterized by oedema with or without congestive cardiac failure.

Because testosterone replacement therapy impairs production of sperm, it should be used with caution in men with fertility concerns. Other conditions can potentially be made worse by testosterone therapy, including sleep apnoea, severe benign prostatic hypertrophy, severe congestive heart failure, or high red blood cell counts (erythrocytosis).

Regular checks on your prostate health during testosterone treatment are recommended as part of routine health care. The amount of red blood cells in the blood should also be checked periodically.

Abuse or overuse of testosterone treatment can be dangerous. For example, using higher than replacement doses to increase muscle bulk can lead to impotence, liver disease, heart attack, and stroke.

Before starting any new treatment, be sure to tell your doctor about any other medication you are taking.

Precautions

Because testosterone replacement therapy impairs production of sperm, it should be used with caution in men with fertility concerns. Other conditions can potentially be made worse by testosterone therapy, including sleep apnoea, severe benign prostatic hypertrophy, severe congestive heart failure, or high red blood cell counts (erythrocytosis).

Regular checks on your prostate health during testosterone treatment are recommended as part of routine health care. The amount of red blood cells in the blood should also be checked periodically.

Abuse or overuse of testosterone treatment can be dangerous. For example, using higher than replacement doses to increase muscle bulk can lead to impotence, liver disease, heart attack, and stroke.

Before starting any new treatment, be sure to tell your doctor about any other medication you are taking.

 

References

  • Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006; 91(6): 1995-2010. Return to content
  • Wang, C., E. Nieschlag, R. Swerdloff, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008, 159(5): 507-514. Return to content